I recently listened to a TED Talk that focused on how your brain reacts to weight loss, and learned about the concept of a set point. The article below is an interesting idea on how to reset that point for permanent weight loss. It targets 10% weight loss annually. However, I believe my body effectively reset it's set point even losing more than that across a 6 month period in 2006. I have been able to return to the same lower weight even after two babies within two years!
http://www.bidmc.org/YourHealth/BIDMCInteractive/BreakThroughYourSetPoint/WeekOneTheScienceofSetPoint.aspx
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